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Inzucchi SE, Zinman B, Fitchett D, Wanner C, Ferrannini E, Schumacher M, et al

Warning signs that require immediate medical attention include severe, persistent abdominal pain that radiates to the back, nausea and vomiting that do not improve with usual anti-nausea strategies, and abdominal tenderness that worsens over hours rather than improving

They did these at both the start and end of the study

The ABCDE rule encompasses visual characteristics such as color, shape, texture, and diameter, which have been utilized in several studies to extract features of skin lesions 6,7,8

2007 Oct;39(10):922-8

Neuroprotective Capabilities: Some research suggests that it may have neuroprotective effects, potentially useful in conditions like Alzheimers disease