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To look for differences between the CRWP and Placebo groups for the physiological assessements a series of mixed, generalized linear models were conducted

Since Cu(I) ions are the direct toxic mediators of cuproptosis, we employed the Cu(I)-specific fluorescent probe Coppersensor-1 (CS1), and observed a significant fluorescence enhancement following Enz treatmentan effect also reversed by TTM (Fig

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However, they do have unique impact on kidney function because of their mechanisms of action

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