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Studies have shown that long-term use of GLP-1 medications is generally safe and effective for both diabetes management and weight loss

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Rats were acclimatized to a controlled environment of 22 1 C temperature and a 12-h light/dark cycle, with free access to food and water, for 2 weeks prior to the experiments

Another study by Watson et al

Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase