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The post says exceeding maximum approved doses raises the risk of acute pancreatitis, severe dehydration, and thyroid side effects with no additional efficacy evidence to justify it

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People taking the highest dose (12 mg) lost an average of 71 pounds over 16 months, starting from an average weight of about 249 pounds

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The glucagon receptor component appears particularly important for this benefit, as glucagon promotes hepatic lipid oxidation, literally helping the liver burn off its excess fat stores