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This randomized, double-blind, placebo-controlled trial showed that treatment with semaglutide alleviated pain related to osteoarthritis of the knee among persons with obesity and knee osteoarthritis, Bliddal and colleagues wrote

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So far, preclinical and observational data examining the effects of GLP1Ra-based therapies on bone suggest a positive association, whereby GLP1Ra use reduces turnover and promotes bone formation (Xie et al., 2025

The purpose of this review is to further elucidate the mechanism of action of GLP-1RAs in helping individuals with overweight or obesity to achieve and maintain weight loss