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Egr-1 stimulation supports vascularization and reduces ischemic tissue damage, according to preclinical research

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ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

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Regular physical activity improves blood circulation and helps prevent or alleviate sexual dysfunction

Excluded from this analysis were clinical trials involving animals or healthy humans, nonrandomized trials, RCTs shorter than 12 weeks, retrospective studies, pooled analyses of clinical trials, conference proceedings, letters to editors, case reports, and articles that lacked relevant data on the outcomes of interest