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Impairment of peripheral circadian clocks precedes metabolic abnormalities in ob/ob mice

9 Nrf2 is usually locked in the cytoplasm, but activation by DMF/MMF allows it to translocate to the nucleus where it activates a pathway of genes involved in antioxidant responses, detoxification, and the activity of cytoprotective anti-inflammatory factors

Genome Biol 16(1):29

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Regulating p53 activity ameliorates various noncancer diseases through the extensive functions of p53