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Mirandola SR, Melo DR, Schuck PF, Ferreira GC, Wajner M, Castilho RF (2008) Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake

The largest study (n=4375) correlating MTHFR effects on venous thrombosis, by Bezemer, found no association with MTHFR 677 (7)

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The opposite of an Agonist is an Antagonist

The study indicates that the process is due to the transdifferentiation between islet cells, and the intestine-islet GLP-1/GLP-1R/PKA signal pathway is one of the important pathways to produce this process (Baggio and Drucker, 2007