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PloS One 17, e0272209

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In humans, kavain undergoes extensive hepatic metabolism, primarily via cytochrome P450 (CYP) enzyme-mediated pathways, followed by further phase II biotransformation processes such as sulfonation, glucuronidation, and glutathione (GSH) conjugation

In the elevated plus maze and open field behavioral tests in rats, intranasal Selank (300 mcg/kg) consistently reduced anxiety-like behaviors, with effects considered comparable to those of classical benzodiazepine drugs[8]