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The patient has established cardiovascular disease with a documented history of at least one of the following: A) Previous myocardial infarction (MI) B) Previous stroke C) Symptomatic peripheral arterial disease (PAD), as outlined above D) Prior coronary revascularization (CABG, PCI, or angioplasty), and

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The osmotic phase occurs immediately after salt exposure and restricts water uptake and cell expansion, whereas the ionic phase develops progressively as toxic ions accumulate in plant tissues

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TIMP-2 inhibits most of MMPs, but it also has a dual action on MMP-2