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* Correspondence: Nada M

The result is uncoordinated, sluggish bowel movements that manifest as constipation

These factors, combined with the complexity of designing clinical trials that adequately account for heterogeneity, timing, and appropriate endpoints, contribute to the difficulty in demonstrating clinical efficacy

Potential Side Effects Typical side effects are local reactions at injection sites, like redness, swelling, or mild pain, which usually subside within days

Am J Phys Med Rehabilt 97(4):248254 Meheux CJ, McCulloch PC, Lintner DM, Varner KE, Harris JD (2016) Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: a systematic review

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