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Oral semaglutide was then investigated in eight global Peptide InnOvatioN for the Early diabEtes tReatment (PIONEER) phase IIIa trials in over 8,000 patients, with similarly broad evaluation in different patient populations who were receiving a range of background medications (33) ( Table 1 )

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For example, GLP-1 agonists have been shown to increase beneficial bacteria such as Bacteroides, Lactobacillus, and Bifidobacterium, while reducing inflammatory species with Enterobacteriaceae

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The hospital-specific file layout and the hospital-specific file are listed with the other supporting documentation for this final rule