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Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial

Nonetheless, even at heavily discounted prices, products such as Wegovy and Zepbound still remain unaffordable for many

Some researchers adjust timing or escalation speed based on body weight

GLP-1 RAs promote satiety, reduce hunger, and dampen reward responsivity, which conceptually could open a temporary low-drive window during which behavioral techniques such as stimulus control, self-monitoring, and structured eating routines become more achievable

Fatigue should be differentiated from hypoglycemia, which can present with similar symptoms including weakness, shakiness, and difficulty concentrating

Tirzepatide treatment was not associated with excess cardiovascular risk (54, 74)