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The dual receptor activation of tirzepatide may produce outcomes in subjects who do not respond adequately to GLP-1 mono-agonism

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Results: Compared to the leading GLP-1RA semaglutide, GL0034 showed increased binding affinity and potency-driven bias in favour of cAMP over GLP-1R endocytosis and -arrestin-2 recruitment

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Patients have reported vision loss and damage to the optic nerve, including rare conditions like non-arteritic anterior ischemic optic neuropathy (NAION) and arteritic anterior ischemic optic neuropathy

and moderately reduce total cholesterol, low-density lipoprotein cholesterol, and triglycerides (82, 83) (Figure 2)