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Genome-wide association analyses have detected critical polymorphisms in genes regulating hepatic lipid handling, including patatin-like phospholipase domain-containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2), which promote intrahepatic triglyceride accumulation by impairing lipid remodeling or very-low-density lipoprotein (VLDL) secretion [16,17]

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(2023) reported that contemporary production techniques offer enhanced sustainability and cost-effectiveness in BC production, making them a significant focus for subsequent studies

Known genetic biomarkers of changes in VPA metabolism are summarized by us and presented in Appendix A