Megahed MM, El-Menshawy AM, Ibrahim AM
References Lau, D., Erichsen, L., Francisco, A., Satylganova, A., Roux, C., McGowan, B., Pedersen, S., Pietilinen, K., Rubino, D., & Batterham, R
Further study is needed to elucidate the risk relationship between GLP-1 RAs and CI, mechanisms for development of CI with GLP-1 RAs, and whether tirzepatide is associated with a higher risk of CI despite its similar gastrointestinal adverse effect profile when compared with other GLP-1 RAs
The process through which NAION destroys vision involves these sequential pathological events: Sudden blood supply disruption: Short posterior ciliary arteries feeding the optic nerve become blocked or experience severe flow reduction, starving nerve tissue Immediate nerve tissue death: Ischemic damage kills optic nerve cells within hours once dead, these neurons cannot regenerate Compartment syndrome: Initial swelling compresses remaining healthy nerve fibers in the confined scleral canal space, creating cascading damage Permanent structural changes: The optic nerve develops atrophy, with dead tissue replaced by glial scarring unable to transmit visual signals NAION commonly affects individuals with crowded optic discs or disc at risk, where cup-to-disc ratio measures 0.2 or less
Effective across a broad range of research workflows, providing a reliable option when both sterility and isotonicity are required
doi: 10.1038/nature07733
