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Clinical data suggest that gastrointestinal side effects are most prominent during the initial weeks of treatment and particularly during the first few days following dose escalation

Resulting in a decrease in blood glucose in a naive, chronically vagotomized, GLP-1 receptor knockout (KO) mouse model

It is an important concept in pharmacology, as it helps to determine the dosage and frequency of drug administration

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[78] These metabolic effects may require monitoring and potential intervention, especially during prolonged therapy