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By modifying polymer composition, crosslinking density, or incorporation of functional moieties, hydrogels can be engineered with precise mechanical stiffness, porosity, and swelling behavior [131]

A researcher drawing from a vial twice a day is putting it under significantly more stress than someone drawing from it every other day

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doi: 10.1016/j.taap.2014.05.010

Inhibition of the PI3K/AKT also leads to decrease in TNF-, IL-6, MMP-2, and MMP-9 production, which suppresses cell proliferation and invasion, and promote apoptosis in cultured RA-FLS 54