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Conclusion We conclude that addition of ALC therapy is superior to metformin plus pioglitazone in ameliorating insulin resistance, polycystic ovaries, menstrual irregularities, and hypoadiponectinemia in women with PCOS

Nevertheless, we arrived at similar results when the per-protocol analysis was applied, despite half of the patients in each group not being included in the analyses

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Weight gain, irregular ovulation, and mood or metabolic effects often follow, so many people with PCOS face a cycle of stubborn weight, menstrual dysfunction, and a higher risk for type 2 diabetes and heart disease

Therefore, it demonstrates significant efficacy in weight loss, blood sugar control, and cardiovascular protection, making it an important treatment option for type 2 diabetes patients and individuals managing their weight

3B, Supplemental Fig