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Retatrutide remains an investigational compound in Phase 3 clinical trials and is not approved by Health Canada for human or veterinary use

In our present study, we determined the genetic proxy efficacy of GLP-1R-based agonists in reducing BMI and ameliorating metabolic risk factors

By reducing appetite and increasing feelings of fullness, GLP-1 diets naturally shift focus towards lower calorie density and fewer empty calories

Nature Medicine, 30(7), 2037-2048

Akkermansia muciniphila and microbial strains that produce butyrate such as Clostridium butyricum can augment GLP-1 production through natural stimulation of the L-cells