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Folic acid is the most oxidized folate form

However, for patients who want nutritional metabolic support especially those with identified deficiencies in choline or B vitamins they may provide a reasonable complement to evidence-based weight management strategies

Cell 140 , 704716 (2010)

Rare Complications and Contraindications Even though its rare, serious problems can happen with Vitamin B12 shots

CR includes reducing calorie intake over a given period while maintaining essential nutrients

If any of these systems are compromised due to leaky gut syndrome or other biological deficiencies, the supplement can be less effective