Semaglutide and orforglipron activate only the GLP-1 receptor, producing appetite suppression through hypothalamic signaling, delayed gastric emptying, and enhanced satiety
Mounjaro (tirzepatide) injections The most effective weight loss treatment currently available, Mounjaro is a weekly injection containing tirzepatide, which works on two hormones, GLP-1 and GIP , to help reduce appetite and cravings, keep you feeling fuller for longer, and regulate blood sugar
How Do They Compare
Do not use GLP-1s if you are pregnant or breastfeeding, or planning to become pregnant or breastfeed
The physiology of glucagon-like peptide-1
Those currently treated privately with a 2.4mg semaglutide injection once weekly can be transitioned straight to semaglutide 25mg tablets once daily, according to the MHRA