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A separate Phase 2 trial in Lancet (Rosenstock et al., 2023) tested retatrutide in 281 adults with type 2 diabetes and showed HbA1c reduction plus 16.94% weight loss at 36 weeks in the highest studied arm

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The doctor may need to consider prior dose, side effects, current appetite, blood sugar status, constipation or nausea history, hydration, weight trajectory, lab markers, cost, access, and maintenance goals