One partner may need different dosing than the other
10.1111/jcmm.18016 202 WangX.YinH.FanL.ZhouY.TangX.FeiX.et al (2021b)
Other animal studies have also shown that asparagus may help regulate lipid metabolism, lower cholesterol levels, reduce blood pressure, and promote weight loss in mice
Table 1 Formation of major oxidants
Phase 2 Trial Design Participants: 338 adults with obesity (BMI 30) or overweight with comorbidities (BMI 27), without diabetes Duration: 48 weeks Dosing groups: Placebo, 1mg, 4mg, 8mg, or 12mg weekly (with gradual dose escalation over 20-24 weeks) Primary endpoint: Percentage change in body weight from baseline Beyond Weight Loss: Metabolic Improvements Beyond weight loss, the 12mg dose also improved several cardiometabolic markers: Blood pressure: Systolic BP decreased by 7.4 mmHg (clinically significant reduction) Lipids: Triglycerides fell 30%, HDL cholesterol increased 8% Glucose control: HbA1c decreased 0.4% even in participants without diabetes Liver health: Markers of fatty liver disease (ALT, AST) improved significantly Inflammation: C-reactive protein (CRP) decreased, indicating reduced systemic inflammation What this means: Retatrutide appears to improve the metabolic dysfunction behind obesity-related diseases, not just the weight itself
10.1016/j.physbeh.2010.02.005 289 Westerterp-PlantengaM
