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This phenomenon, called treatment resistance, affects roughly 20-30% of GLP-1 users and stems from individual differences in receptor sensitivity, genetic predispositions, and medication formulation

However, despite the positive results compared to other therapies, only a fraction of patients are responsive to ICI treatment (Haslam and Prasad, 2019

Dutta P, Kumar Y, Babu AT, Ravindran SG, Salam A, Rai B, Baskar A, Dhawan A, Jomy M

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ashwagandha can be taken with or without food, but how you take it may affect absorption and tolerance: With food: If you have a sensitive stomach, taking ashwagandha with a meal can help reduce the chance of digestive discomfort

doi: 10.1038/nm0106-75