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We showed that our model accurately reproduces published clinical and experimental data on the dose-dependent time course of acetaminophen in the plasma, the accumulation of acetaminophen and its metabolites in the urine, and the depletion of glutathione caused by conjugation with the toxic product

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Microdosing may lead to unpredictable side effects and interactions with other medications

(2) Activation of the AGERAGE pathway induces ROS generation, which, in combination with mitochondrial dysfunction under diabetic conditions, exacerbates myocardial injury, further accelerates atrial remodeling, and promotes AF development (57, 58)

The thyroid gland becomes infiltrated predominantly by cytotoxic T cells, leading to follicular destruction, fibrosis, and gradual atrophy of the gland

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