Patients with specific genetic predispositions toward slower metabolic adaptation may benefit from more gradual semaglutide dose escalation, reducing the risk that rapid weight loss and metabolic shifts destabilize thyroid hormone balance
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This is particularly relevant for people taking weight loss injections, such as GLP-1 agonists (e.g., Ozempic or Mounjaro), which can sometimes cause fatigue and a feeling of low energy
Environmental factors, including diet and micronutrient availability, may influence disease penetrance and should therefore be considered when interpreting these findings
Conversely, [U- 13 C]glucose tracing showed GGCT overexpression enhanced Glc-derived carbon flux into the TCA cycle (increased m + 2 labeling of succinate, fumarate, malate), which was reversed by the E98A mutant (Fig
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