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Have we defined that well

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Hippocampus 22:723736 Chan A, Shea TB (2007) Effects of dietary supplementation with N -acetyl cysteine, acetyl-l-carnitine and S-adenosyl methionine on cognitive performance and aggression in normal mice and mice expressing human ApoE4

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Think of oxidative stress as the "wear and tear" that happens at a cellular level due to environmental factors, metabolism, and daily living