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As these pressures intensify, employers need a coordinated, long-term approach now that moves beyond access and cost alone to focus on real outcomes, sustained engagement, and financial sustainability

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This tightly regulated process begins with signal detection by microglia through pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), or other damage associated receptors, such as receptor for advanced glycation end products (RAGE) and scavenger receptors, prompting a transition from a surveillant to a reactive state (Kraft and Harry, 2011)

Longa EZ, Weinstein PR, Carlson S, Cummins R