Katsuda TR, Tsuchiya N, Kosaka, et al
Abnormal expression of PDCD1 and CD274 in T cell subsets of PAH patients is associated with enrichment of T cell activation and cytotoxic pathways (Jiang P
Every cell in your body relies on dietary protein not only for tissue growth, but also to regulate the complex hormonal and metabolic processes, nourish eggs and sperm, build the placenta, and even support breast milk production. 
Regarding environmental factors, high iodine intake, selenium deficiency, pollutants such as tobacco smoke, infectious diseases such as chronic hepatitis C, and certain drugs are implicated in the development of autoimmune thyroiditis (16.1: Duntas LH
Carbon 166, 175182
There are two factors at play here