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10.1021/tx700031r 77 SivilottiM

FEMS Immunol

Gough SC, Bode B, Woo V, Rodbard HW, Linjawi S, Poulsen P, et al

The kidney's filtration workload from oral glutathione supplementation is comparable to its workload from any other amino-acid-containing meal nowhere close to the physiological stress of processing high concentrations of intact glutathione delivered directly into systemic circulation via an IV line

According to the vascular hypometabolism hypothesis, amyloid plaques and tau tangles may be consequences rather than root causes of biological stress signals arising when neurons do not receive sufficient blood flow and are under-nourished