Label it with the date and concentration (e.g., "Retatrutide 5 mg/ml, mixed on 03/16/2026")
189 Subsequently, tirzepatide has been extensively investigated in the SURPASS program, a comprehensive development initiative targeting T2DM that is inadequately controlled by various glucose-lowering regimens, including lifestyle alone (SURPASS-1), 190 metformin monotherapy (SURPASS-2), 191 metformin with or without sodium-glucose co-transporter 2 inhibitors (SGLT2i) (SURPASS-3), 192 combination therapy including metformin, SGLT2i, and sulfonylureas (SURPASS-4), 193 insulin glargine with or without metformin (SURPASS-5), 88 and insulin lispro with basal insulin (SURPASS-6)
National Comprehensive Cancer Network
Some healthcare providers may prescribe both off-label in select cases, but this requires careful patient selection, comprehensive cardiovascular screening, and close monitoring for additive side effects including increased heart rate, blood pressure changes, and gastrointestinal symptoms
It is important to note that cross-trial comparisons have significant limitations
Glucose and pyruvate metabolism in severe chronic obstructive pulmonary disease
