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CAFs upon activation secretes growth factors, cytokines, and ECM molecules including TGF-, matrix metalloproteinases (MMPs), hepatocyte growth factor (HGF), and fibroblast growth factors (FGFs), which are implicated in tumor development, invasion, and metastasis (120)

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Triple agonists [12] such as GLP-1RA, GIP-RA plus glucagon-RA are in development and may show comparable efficacy in weight loss to tirzepatide by targeting multiple pathways involved in energy regulation [13]