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It not only protects and detoxifes the cells, but also makes energy levels peak, while optimizing the metabolism

Kaur H, Ganguli D, Bachhawat AK (2012) Glutathione degradation by the alternative pathway (DUG pathway) in Saccharomyces cerevisiae is initiated by (Dug2p-Dug3p)2 complex, a novel glutamine amidotransferase (GATase) enzyme acting on glutathione

2015 NAD+ in aging, metabolism, and neurodegeneration Science Overview of how NAD+ links cellular energy status to sirtuin signaling, mitochondrial function, and neuronal maintenance

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and is associated with a more rapid progression to CKD