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The interaction between Neh4 and Neh5 with the nuclear cofactor RAC3/AIB1/SRC-3 enhances the expression of antioxidant response element (ARE)-containing genes

However, the effects may require repeated treatments for sustained results

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Miyamoto Y, Koh YH, Park YS, Fujiwara N, Sakiyama H, Misonou Y et al

The subcutaneous injection itself involves depositing medication into adipose tissue, which contains sensory nerve fibers

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