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Patients with MS often experience comorbidities including metabolic syndrome, type 2 diabetes, and obesity, which may be exacerbated by reduced mobility and certain treatments, particularly corticosteroids used for acute relapses

The reactions were incubated at 42 C for 2 min, 20 C for 5 min, 25 C for 5 min, 30 C for 5 min, 35 C for 5 min, 37 C for 5 min, 42 C for 45 min, and 2 min at 94 C

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Balestrino M, Rebaudo R, Lunardi G: Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: dose-effect relationship