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Knobs-into-holes engineering of antibody CH3 domains for heavy chain heterodimerization

Researched for accelerated wound healing, musculoskeletal repair, GI mucosal protection, and angiogenesis promotion

Bhattacharyya S, Bakshi R, Logan R, Ascherio A, Macklin EA, Schwarzschild MA

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[DOI] [PubMed] [Google Scholar] 131.Beuzard Y

2 , 3 Conclusion These adverse events were consistent with reactions patients experience with excessive levels of endotoxin, and FDAs testing confirmed higher levels of endotoxin than is appropriate based on the dose of L-glutathione received intravenously