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In this context, the data currently available on tirzepatide, showing its efficacy in glycemic control to the extent that a considerable percentage of patients achieve glucose levels indicative of diabetes remission [3, 59], as well as its high effectiveness in weight management, are promising regarding its future use in clinical practice

GLP-1 RAs have shown promising effects in the treatment of HS, but limitations exist in the current literature

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Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function

Tirzepatide (26.6%) but long-term safety and effectiveness are still being studied for retatrutide