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As part of a larger crackdown on direct-to-consumer prescription drug advertising, the FDA published over 55 warning letters on September 16 to online sellers of compounded versions of the popular GLP-1 medications for type-2 diabetes and weight loss

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Although it has been hypothesized that the GLP1-RAs effects on T levels were mainly mediated via weight loss, direct GLP.1 interactions with the HPG axis cannot be excluded