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Zepbound is administered as a once-weekly subcutaneous injection, with dosing typically starting at 2.5 mg for 4 weeks, then increasing by 2.5 mg every 4 weeks as tolerated (through intermediate steps of 5 mg, 7.5 mg, 10 mg, 12.5 mg) to a maintenance dose of 5 mg, 10 mg, or 15 mg based on individual response and tolerability

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Following the extraction, the samples were derivatized by transferring 600 l (500 l for erythrocyte samples) of the solution into a glass tube, and adding 120 l of iodoacetic acid (IAA, 7.4 mg/ml)

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