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The current 4-week-per-dose-level schedule was specifically designed to minimize GI side effects while reaching therapeutic doses in a reasonable timeframe

Stomach Emptying: They slow down how quickly food leaves your stomach, keeping you satisfied longer after meals

Cyclin dependent kinase-4 Following cyclin C1 binding, CDK4 phosphorylates critical substrates for cell progression through the cell cycle

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Regarding the rest of the biomarkers, univariate ANCOVA with BMI adjustment was used with variables fitting a normal distribution and the Mann Whitney U test for those not fitting the normal distribution