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In RA, persistent synovitis and systemic inflammation underlie disease pathology, and therapies targeting pro-inflammatory cytokinessuch as DMARDsameliorate joint destruction and improve outcomes (84)

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Microbiome + SCFAs: The Foundation for Natural GLP-1 Signalling The gut microbiome ferments fiber into short-chain fatty acids (SCFAs) butyrate, propionate, acetate

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