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Four of the 6 (66.7%) RCTs were classified as having high RoB, and 2 (33.3%) were classified as having low RoB
Researchers have documented the safety profile observed in published Phase 2 research as predominantly gastrointestinal effects (nausea, diarrhoea, vomiting) typical of the incretin class, occurring most prominently during dose escalation and tending to decline with continued exposure (PMID 39515565, PMID 41785010)
Orlistat is a tablet that blocks some dietary fat absorption modest weight loss but a long safety record
While not always a washout, the principle of planned timing is consistent
Advertisement Clinical Research and Public HealthEndocrinologyNeuroscience Free access | 10.1172/JCI151800 1 Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
These include the glucagon receptor, GLP-1 pathways, and GIP signalling
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