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Therefore, we speculate that in genetically predisposed individuals, the environmental context that triggers MetS (i.e., sedentary lifestyle) may also be an important trigger for the development and severity of vitiligo disease

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Tophi often form several years after the first gout attack and in some cases they appear in people who have never had a gout attack

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DIO1 activity may also be involved in regulating iodine homeostasis (46)