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First, entry criteria for these trials could be as broad as possible to both improve the ability to generalize the results and permit subgroup analysis

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Individual CES-D scores were also categorized into 3 groups based on total score, including minimal/mild (total scores 015), moderate (total scores 1624) and severe (total scores 25) (84, 85)

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Some individuals progress through standard dosing, while others may need adjustments for faster results, fewer side effects, or better long-term maintenance