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16 Surprisingly, replacing GIP Lys 16 with Ala promotes the insulinotropic effect of GIP

or with a BMI of 27 or more and pre-diabetes, previous myocardial infarction, previous stroke, or symptomatic peripheral artery disease

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consulting fees from Boehringer Ingelheim, GSK and Otsuka and speaking fees from Amgen and Sanofi (Mexico), but has not received funding in relation to the writing of this article

What Are GLP-1s

Lixisenatide, a structurally modified derivative of exendin-4, addresses some of these limitations by offering a longer half-life of approximately 3 h, thereby permitting once-daily dosing (Leon et al., 2017)