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Clinically, it may be particularly helpful in patients with: Wheezing or respiratory symptoms Persistent hives or itching Abdominal cramping related to smooth muscle activation Studies in chronic idiopathic urticaria have shown that montelukast may reduce itch severity and hive frequency in some patients, particularly when used as adjunctive therapy

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[273] For example, during the early 1970s in the United States, amphetamine became a schedule II controlled substance under the Controlled Substances Act