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Cagrilintide has been characterized in peer-reviewed research and clinical investigation as a potent, selective amylin receptor agonist with an extended pharmacokinetic profile suitable for once-weekly dosing paradigms
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Semaglutide works by: Slowing gastric emptying , which helps you feel fuller for longer after meals Reducing appetite by acting on areas of the brain that regulate hunger and food intake Improving blood sugar control by stimulating insulin secretion when blood glucose levels are elevated Decreasing glucagon secretion , which helps prevent the liver from releasing excess glucose Wegovy is administered as a once-weekly subcutaneous injection , typically in the abdomen, thigh, or upper arm
[1] [2] The decision to use these medications concurrently should always be made by your prescribing clinician , who will consider your complete medical history, current medications, and individual risk factors
The SELECT trial (NEJM, 2023) demonstrated that semaglutide 2.4mg reduced major adverse cardiovascular events (MACE) by 20% in over 17,000 patients with overweight/obesity and established cardiovascular disease, without diabetes