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Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity

Semaglutide overcomes this through two structural modifications: an alanine-to-Aib substitution at position 8 (which removes the DPP-4 cleavage site) and the attachment of a C18 fatty diacid chain via a bifunctional linker at lysine position 26

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"Thymosin Beta 4 Clinical Development Program." Phase II Data, 2010