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In patients with active IBD, pro-inflammatory cytokines such as TNF-, IL-1, IL-6, IL-12, and IL-23 are significantly elevated, while anti-inflammatory cytokines such as IL-10 and IL-4 are expressed at insufficient levels [59, 60]

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The following chemical reactions are catalyzed by XO (Figure 16): Inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions

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